Increasingly, it is clear that all emotional and thought disorders result from misfiring of specific circuits in the brain which normally help process cognitive and emotional content, and that consistent anatomic patterns of this misfiring are seen whether the problem results from emotional trauma, spontaneously, from a head injury, or from any other cause.   Advances in brain imaging and AI has made it possible to understand these circuits and localize them in the brain.  Our recent advances have led to revolutionary products which make it possible to see the mental illness in the brain, and to use these facts to determine the best way to treat a patient.  All things that improve someone’s mental health do so by changing how something in the brain works, and we now can truly link our approaches to biologic reality.