In the pursuit of extended human lifespan, the potential of psychedelics emerges as a fascinating frontier in longevity medicine. This keynote delves into the profound implications of these compounds, highlighting their capacity to rejuvenate both mind and body, thus playing a crucial role in healthy aging and longevity. Unearth the intersection of ancient psychedelic practices and modern longevity research, paving the way for a future of enhanced well-being and extended lifespans.