People are living longer – no longer because of reduced child mortality, but because we are postponing the ill-health of old age. But we’ve seen nothing yet: regenerative medicine and other new therapies will eventually be so comprehensive that people will stay truly youthful however long they live, which means they may mostly live very long indeed. Advances in this direction by my research teams and others have sharply accelerated in recent years, and at LEV Foundation we are combining them to identify a panel of interventions that promise to deliver the ultimate goal of biomedical gerontology: longevity escape velocity. I will discuss the latest results of this work, which is currently the world’s only study combining several rejuvenation interventions in middle-aged mice.